Break Free

โ€œGoing Outโ€ of the Box: Close Intercultural Friendships and Romantic Relationships Spark Creativity, Workplace Innovation, and Entrepreneurship.

Not surprising to me at all. I know it’s firmly against the lib re-segregation urges these days, but you learn so much more and have a vastly better life when you don’t be friends with and date people exactly like you, and in that I include people exactly the same age as you.

What is it with the liberal urge to have life as regimented as army basic training? How the hell did that happen? I remember when it was completely the opposite, and it was not that long ago, either.

Space Appraisal

What Kelly says is not wrong, exactly, but it is misleading because it misses vast amounts of complexity and caveats. Certainly, SARS2 having more hosts in which to evolve is not ideal. But the virus, as with all of us, neither has infinite flexibility nor infinite capability to achieve optimum configurations. There are many superior protein arrangements that we can imagine, and many that we might be able to artificially place it (and similar viruses) into that it can never achieve via evolution.

Explaining exactly why would take far too long and most of you would need to read quite a few textbooks before that, but here’s a diagram that relates:

This is much, much simplified, but the virus started at 1, which was metastable (from our perspective). The variants will tend to take it to 3, a stable equilibrium. To go beyond that, there is a much, much harder hill to climb to reach beyond 3, and no natural evolutionary process can do so for the most-optimum configurations.

I think there’s only about a 50% chance I’ll be right, but I expect the Delta variant to be the last or the next-to-last variant to emerge that is significantly more harmful than others. With the number of hosts infected, and the limited configuration space for ACE2 receptor binding, I expect SARS2 is about out of tricks.

As ever, though, time will tell the full tale.

Imprisoning

People love prison countries, it appears.

Makes no sense for people who have been vaccinated. And in general is probably not that helpful outside of that (now).

I know a lot of you parochial-ass motherfuckers don’t know anyone outside of your tiny area, but a lot of people have friends and loved ones overseas. Where’s your “open borders” bullshittery at now?