A graph that is definitely worth thousands of words. Why is it has it been so hard to develop effective drugs since 2000 compared to the prior decades? This figure says it all. https://t.co/6sDtWpqdvL pic.twitter.com/RxuuDqgeUG

— Ethan Mollick (@emollick) March 6, 2021

Ha! Pre-registration broke p-hacking, so fewer non-working meds get through the pipe. I didn’t think about that, but it makes total sense.